Research

Phylogenetics

How to record and represent evolution? What are the patterns observed in pathogen evolution? What mathematical models can reproduce the evolutionary patterns? How to predict evolution? What can we learn from the evolution of pathogens to help solve problems in public health and medicine?

Publications and preprints

Analyzing phylogenetic trees with a tree lattice coordinate system and a graph polynomial
Pengyu Liu, Priscila Biller, Matthew Gould and Caroline Colijn
Systematic Biology, 2022

The impact of sampling bias on viral phylogeographic reconstruction
Pengyu Liu, Yexuan Song, Caroline Colijn and Ailene MacPherson
PLOS Global Public Health, 2022

Comparing the topology of phylogenetic network generators
Remie Janssen and Pengyu Liu
Journal of Bioinformatics and Computational Biology, 2021

A tree distinguishing polynomial
Pengyu Liu
Discrete Applied Mathematics, 2021

Invited Conference Talks

  • Comparing the topology of phylogenetic network generators
    RECOMB – Comparative Genomics, Online
    September 2021
  • A tree distinguishing polynomial - an introduction to polynomial tree metrics
    SMB Annual Meeting, Université de Montréal, Montréal, QC
    July 2019
  • A tree distinguishing polynomial - an introduction to polynomial tree metrics
    CAIMS Annual Meeting, Whistler, BC
    June 2019
  • A tree distinguishing polynomial - an introduction to polynomial tree metrics
    CanaDAM 2019, Simon Fraser University, Vancouver, BC
    May 2019

Infectious diseases

What are the patterns in infectious diseases transmission? How is human behavior related to the heterogeneous patterns of infectious disease distribution in host populations? How can genomic data help in analyzing and predicting infectious disease transmission?

Publications and preprints

Using machine learning to detect coronaviruses potentially infectious to humans
Georgina Gonzalez-Isunza, Muhammad-Zaki Jawaid, Pengyu Liu, Daniel Cox, Mariel Vázquez, Javier Arsuaga
Scientific Reports, 2023

The potential of genomics for infectious disease forecasting
Jessica Stockdale, Pengyu Liu, and Caroline Colijn
Nature Microbiology, 2022

Modelling the impact of household size distribution on the transmission dynamics of COVID-19
Pengyu Liu, Lisa McQuarrie, Yexuan Song and Caroline Colijn
Journal of the Royal Society Interface, 2021

Media Coverage

  • B.C. researchers say genomic data can improve pandemic modelling
    North Shore News
    October 2022
  • Crowded households and COVID-19
    CBC Radio - On The Coast with Gloria Macarenko
    April 2021
  • A COVID culprit: crowded households. And more news from science journals
    The Tyee
    April 2021
  • Her husband got COVID-19. She’s suing his employer
    Bloomberg Opinion
    February 2021

Social science and linguistics

Why do stock prices fluctuate? What is the role of conformity and anticonformity in determining stock prices? Why are we experiencing more communities internally conflicting or extremizing as the internet develops? Do the shapes of social networks have effects on this? How to measure syntax diversity in language acquisition? Is Korean more similar to Chinese or Turkish in terms of syntax?

Publications and preprints

Effects of network topology and trait distribution on collective decision making
Pengyu Liu and Jie Jian
AIMS Mathematics, 2023

Quantifying syntax similarity with a polynomial representation of dependency trees
Pengyu Liu, Tinghao Feng and Rui Liu
Glottometrics, 2022


Topology

What is topology? What are knots and links? How to efficiently compute invariants of knots and links? Can we find more invariants of knots and links, especially the ones that are easy to compute?

Publications and preprints

A diagrammatic approach for determining the braid index of alternating links
Yuanan Diao, Claus Ernst and Gábor Hetyei and Pengyu Liu
Journal of Knot Theory and Its Ramifications, 2021

The braid index of reduced alternating links
Yuanan Diao, Gábor Hetyei and Pengyu Liu
Mathematical Proceedings of the Cambridge Philosophical Society, 2020

The HOMFLY polynomial of links in closed braid form
Pengyu Liu, Yuanan Diao and Gábor Hetyei
Discrete Mathematics, 2019

Invited Conference Talks

  • A diagrammatic approach for determining the braid index of alternating links
    The Geometry and Topology of Knotting and Entanglement in Proteins, CMO-BIRS Workshop, Oaxaca, Mexico
    November 2017
  • The braid index of reduced alternating links
    AMS Sectional Meeting, University of Saint Thomas, Minneapolis, MN
    October 2016
  • The HOMFLY polynomial of links in closed braid form
    Workshop on Graphs and Knots, Xiamen University, Xiamen, China
    June 2016

Structural genomics

What are the structures of genomes and proteins that appear in nature? How do they form and what are their origins? What structures cause diseases? How do they cause diseases? What genomic or protein structures are in pathogens? How to model different structures of genomes?

Publications and preprints

Characterizing the topology of kinetoplast DNA using random knotting
Pengyu Liu, Ryan Polischuk, Yuanan Diao and Javier Arsuaga
Topology and Geometry of Biopolymers, Contemporary Mathematics, 2020

Estimating properties of kinetoplast DNA by fragmentation reactions
Lara Ibrahim, Pengyu Liu, Michele Klingbeil, Yuanan Diao and Javier Arsuaga
Journal of Physics A: Mathematical and Theoretical, 2019

Invited Conference Talks

  • Monte-Carlo Model for Kinetoplast DNA Networks
    CAIMS Annual Meeting, University of British Columbia, Kelowna, BC
    June 2022
  • Estimating properties of kinetoplast DNA by fragmentation reactions
    Workshop on Knotted Fields, Beijing University of Technology, Beijing, China
    September 2019

Events

12/9-12/13, 2024 Auckland, New Zealand

NZMS AustMS AMS Joint Meeting 2024

The Joint Meeting of the New Zealand, Australian and American Mathematical Societies


9/4-12/6, 2024 Providence, RI, USA

ICERM Semester Program

Theory, Methods, and Applications of Quantitative Phylogenomics


7/8-7/12, 2024 Spokane, WA, USA

SIAM AN24

The Annual Meeting of Society for Industrial and Applied Mathematics


5/31-6/2, 2024 Saskatoon, SK, Canada

CMS Summer Meeting

2024 Canadian Mathematical Society Summer Meeting


3/17-3/22, 2024 Banff, AB, Canada

BIRS Workshop

The Crossroads of Topology, Combinatorics and Biosciences


1/3-1/6, 2024 San Francisco, CA, USA

JMM 2024

Joint Mathematics Meetings


1/4-1/7, 2023 Boston, MA, USA

JMM 2023

Joint Mathematics Meetings


11/9-11/16, 2022 Online

8MWTopology

The 8th Mexican Workshop on Applied Geometry and Topology


10/22-10/23, 2022 Salt Lake City, UT, USA

AMS Sectional Meeting

Fall Western Sectional Meeting


6/13-6/16, 2022 Kelowna, BC, Canada

CAIMS 2022

The Annual Meeting of the Canadian Society of Applied and Industrial Mathematics